White Matter Anisotropy for Impact Simulation and Response Sampling in Traumatic Brain Injury.

ABSTRACT: Advanced neuroimaging provides new opportunities to enhance head injury models, including the incorporation of white matter (WM) structural anisotropy. Information from high-resolution neuroimaging, however, usually has to be "down-sampled" to match a typically coarse brain mesh. To understand how this mesh-image resolution mismatch affects impact simulation and subsequent response sampling, we compared three competing anisotropy implementations (using either voxels, tractography, or a multiscale submodeling) and two response sampling strategies (element-wise or tractography-based, using brain mesh or neuroimaging for region segmentation, respectively). Using the combination of high resolution options as a baseline, we studied how the choice in each individual category affected the resulti

SUBMITTER: Zhao W 

PROVIDER: S-EPMC6338585 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature