Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring.

ABSTRACT: Infants of obese mothers have an increased risk of developing obesity, insulin resistance, and type 2 diabetes. The underlying mechanisms remain elusive, and no effective interventions to limit the transmission of metabolic disease from the obese mother to her infant are currently available. Obese pregnant women have decreased circulating levels of adiponectin, which is associated with increased placental nutrient transport and fetal overgrowth. We have reported that normalization of adiponectin levels during late gestation reversed placental dysfunction and fetal overgrowth in a mouse model of maternal obesity in pregnancy. In the current study, we hypothesized that adiponectin supplementation during pregnancy in obese mice attenuates the adverse metabolic outcomes in adult offspring. Adu

SUBMITTER: Paulsen ME 

PROVIDER: S-EPMC6338628 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature