Plasma glycomics predict cardiovascular disease in patients with ART-controlled HIV infections.

ABSTRACT: Despite effective control of HIV infection with antiretroviral drugs, individuals with HIV have high incidences of secondary diseases. These sequelae, such as cardiovascular disease (CVD), are poorly understood and represent a major health burden. To date, predictive biomarkers of HIV-associated secondary disease have been elusive, making preventative clinical management essentially impossible. Here, we applied a newly developed and easy to deploy, multitarget, and high-throughput glycomic analysis to banked HIV⁺ human plasma samples to determine whether the glycome may include biomarkers that predict future HIV-associated cardiovascular events or CVD diagnoses. Using 324 patient samples, we identified a glycomic fingerprint that was predictive of future CVD events but independe

SUBMITTER: Oswald DM 

PROVIDER: S-EPMC6338643 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature