Proteo-Transcriptomic Dynamics of Cellular Response to HIV-1 Infection.

ABSTRACT: Throughout the HIV-1 replication cycle, complex host-pathogen interactions take place in the infected cell, leading to the production of new virions. The virus modulates the host cellular machinery in order to support its life cycle, while counteracting intracellular defense mechanisms. We investigated the dynamic host response to HIV-1 infection by systematically measuring transcriptomic, proteomic, and phosphoproteomic expression changes in infected and uninfected SupT1 CD4+ T cells at five time points of the viral replication process. By means of a Gaussian mixed-effects model implemented in the new R/Bioconductor package TMixClust, we clustered host genes based on their temporal expression patterns. We identified a proteo-transcriptomic gene expression signature of 388 host genes speci

SUBMITTER: Golumbeanu M 

PROVIDER: S-EPMC6338737 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature