A validation of the diathesis-stress model for depression in Generation Scotland.

ABSTRACT: Depression has well-established influences from genetic and environmental risk factors. This has led to the diathesis-stress theory, which assumes a multiplicative gene-by-environment interaction (GxE) effect on risk. Recently, Colodro-Conde et al. empirically tested this theory, using the polygenic risk score for major depressive disorder (PRS, genes) and stressful life events (SLE, environment) effects on depressive symptoms, identifying significant GxE effects with an additive contribution to liability. We have tested the diathesis-stress theory on an independent sample of 4919 individuals. We identified nominally significant positive GxE effects in the full cohort (R² = 0.08%, p = 0.049) and in women (R² = 0.19%, p = 0.017), but not in men (R² = 0.15%,

SUBMITTER: Arnau-Soler A 

PROVIDER: S-EPMC6338746 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature