Detection of anthracycline-induced cardiotoxicity using perfusion-corrected ^99mTc sestamibi SPECT.

ABSTRACT: By the time cardiotoxicity-associated cardiac dysfunction is detectable by echocardiography it is often beyond meaningful intervention. ^99mTc-sestamibi is used clinically to image cardiac perfusion by single photon emission computed tomography (SPECT) imaging, but as a lipophilic cation its distribution is also governed by mitochondrial membrane potential (ΔΨ_m). Correcting scans for variations in perfusion (using a ΔΨ_m-independent perfusion tracer such as (bis(N-ethoxy-N-ethyldithiocarbamato)nitrido ^99mTc(V)) (^99mTc-NOET) could allow ^99mTc-sestamibi to be repurposed to specifically report on ΔΨ_m as a readout of evolving cardiotoxicity. Isolated rat hearts were perfused within a γ-detection apparatus to characteriz

SUBMITTER: Safee ZM 

PROVIDER: S-EPMC6338786 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature