Klebsiella pneumoniae prevents spore germination and hyphal development of Aspergillus species.

ABSTRACT: Different bacteria and fungi live as commensal organisms as part of the human microbiota, but shifts to a pathogenic state potentially leading to septic infections commonly occur in immunocompromised individuals. Several studies have reported synergistic or antagonistic interactions between individual bacteria and fungi which might be of clinical relevance. Here, we present first evidence for the interaction between Klebsiella pneumoniae and several Aspergillus species including A. fumigatus, A. terreus, A. niger and A. flavus which cohabit in the lungs and the intestines. Microbiological and molecular methods were employed to investigate the interaction in vitro, and the results indicate that Klebsiella pneumoniae is able to prevent Aspergillus spp. spore germination and hyphal developmen

SUBMITTER: Nogueira MF 

PROVIDER: S-EPMC6338788 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature