Association between TMPRSS2:ERG fusion gene and the prostate cancer: systematic review and meta-analysis.

ABSTRACT:

Introduction

To identify the association between the TMPRSS2:ERG fusion gene, their variants and the onset of localized prostate cancer.

Material and methods

A systematic search strategy was carried out through MEDLINE, EMBASE, LILACS, CENTRAL and unpublished literature. We included randomized control trials, cohort, case-control and cross-sectional studies that involved patients >18 years-old assessing the association between TMPRSS2 fusion gene, its single nucleotide polymorphisms and prostate cancer. The primary outcome was prostate cancer defined by histology of the tumor coming from transrectal ultrasound guided biopsy, transurethral resection of the prostate or radical prostatectomy. We assessed the risk of bias with QUADAS2 and performed a meta-analysis with Stata 14.

SUBMITTER: Garcia-Perdomo HA 

PROVIDER: S-EPMC6338815 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature