The genomic basis of Red Queen dynamics during rapid reciprocal host-pathogen coevolution.

ABSTRACT: Red Queen dynamics, involving coevolutionary interactions between species, are ubiquitous, shaping the evolution of diverse biological systems. To date, information on the underlying selection dynamics and the involved genome regions is mainly available for bacteria-phage systems or only one of the antagonists of a eukaryotic host-pathogen interaction. We add to our understanding of these important coevolutionary interactions using an experimental host-pathogen model, which includes the nematode Caenorhabditis elegans and its pathogen Bacillus thuringiensis We combined experimental evolution with time-shift experiments, in which a focal host or pathogen is tested against a coevolved antagonist from the past, present, or future, followed by genomic analysis. We show that (i

SUBMITTER: Papkou A 

PROVIDER: S-EPMC6338873 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature