BRCA mutation screening and patterns among high-risk Lebanese subjects.

ABSTRACT:

Background

Previous studies have suggested that the prevalence of BRCA1 and 2 mutations in the Lebanese population is low despite the observation that the median age of breast cancer diagnosis is significantly lower than European and North American populations. We aimed at reviewing the rates and patterns of BRCA1/2 mutations found in individuals referred to the medical genetics unit at the American University of Beirut. We also evaluated the performance of clinical prediction tools.

Methods

We retrospectively reviewed the cases of all individuals undergoing BRCA mutation testing from April 2011 to May 2016. To put our findings in to context, we conducted a literature review of the most recently published data from the region.

Results

Two-h

SUBMITTER: Farra C 

PROVIDER: S-EPMC6339325 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature