Short-term consumption of a high-fat diet increases host susceptibility to Listeria monocytogenes infection.

ABSTRACT:

Background

A westernized diet comprising a high caloric intake from animal fats is known to influence the development of pathological inflammatory conditions. However, there has been relatively little focus upon the implications of such diets for the progression of infectious disease. Here, we investigated the influence of a high-fat (HF) diet upon parameters that influence Listeria monocytogenes infection in mice.

Results

We determined that short-term administration of a HF diet increases the number of goblet cells, a known binding site for the pathogen, in the gut and also induces profound changes to the microbiota and promotes a pro-inflammatory gene expression profile in the host. Host physiological changes were concordant with significantly increased susceptibility to o

SUBMITTER: Las Heras V 

PROVIDER: S-EPMC6339339 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature