Dataset Information

Comparative analysis reveals the Genomic Islands in Pasteurella multocida population genetics: on Symbiosis and adaptability.

ABSTRACT:

Background

Pasteurella multocida (P. multocida) is a widespread opportunistic pathogen that infects human and various animals. Genomic Islands (GIs) are one of the most important mobile components that quickly help bacteria acquire large fragments of foreign genes. However, the effects of GIs on P. multocida are unknown in the evolution of bacterial populations.

Results

Ten avian-sourced P. multocida obtained through high-throughput sequencing together with 104 publicly available P. multocida genomes were used to analyse their population genetics, thus constructed a pan-genome containing 3948 protein-coding genes. Through the pan-genome, the open evolutionary pattern of P. multocida was revealed, and the functional components of 944 core genes, 2439 accessory genes and 565 unique genes were analysed. In addition, a total of 280 GIs were predicted in all strains. Combined with the pan-genome of P. multocida, the GIs accounted for 5.8% of the core genes in the pan-genome, mainly related to functional metabolic activities; the accessory genes accounted for 42.3%, mainly for the enrichment of adaptive genes; and the unique genes accounted for 35.4%, containing some defence mechanism-related genes.

Conclusions

The effects of GIs on the population genetics of P. multocida evolution and adaptation to the environment are reflected by the proportion and function of the pan-genome acquired from GIs, and the large quantities of GI data will aid in additional population genetics studies.

SUBMITTER: Zhu D

PROVIDER: S-EPMC6339346 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Comparative analysis reveals the Genomic Islands in Pasteurella multocida population genetics: on Symbiosis and adaptability.

Zhu Dekang D He Jiao J Yang Zhishuang Z Wang Mingshu M Jia Renyong R Chen Shun S Liu Mafeng M Zhao Xinxin X Yang Qiao Q Wu Ying Y Zhang Shaqiu S Liu Yunya Y Zhang Ling L Yu Yanling Y You Yu Y Chen Xiaoyue X Cheng Anchun A

BMC genomics 20190118 1

<h4>Background</h4>Pasteurella multocida (P. multocida) is a widespread opportunistic pathogen that infects human and various animals. Genomic Islands (GIs) are one of the most important mobile components that quickly help bacteria acquire large fragments of foreign genes. However, the effects of GIs on P. multocida are unknown in the evolution of bacterial populations.<h4>Results</h4>Ten avian-sourced P. multocida obtained through high-throughput sequencing together with 104 publicly available ...[more]

PMID: 30658579

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Dataset Information

Comparative analysis reveals the Genomic Islands in Pasteurella multocida population genetics: on Symbiosis and adaptability.

Background

Results

Conclusions

Publications

Comparative analysis reveals the Genomic Islands in Pasteurella multocida population genetics: on Symbiosis and adaptability.

Similar Datasets

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