<i>APOL1</i> Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults.

ABSTRACT:

Background

APOL1 renal risk variants are strongly associated with chronic kidney disease in Black adults, but reported associations with cardiovascular disease (CVD) have been conflicting.

Methods

We examined associations of APOL1 with incident coronary heart disease (n=323), ischemic stroke (n=331), and the composite CVD outcome (n=500) in 10 605 Black participants of the REGARDS study (Reasons for Geographic and Racial Differences in Stroke). Primary analyses compared individuals with APOL1 high-risk genotypes to APOL1 low-risk genotypes in Cox proportional hazards models adjusted for CVD risk factors and African ancestry.

Results

APOL1 high-risk participants were younger and more likely to have albuminuria at baseline than APOL

SUBMITTER: Gutierrez OM 

PROVIDER: S-EPMC6339526 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature