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SWI/SNF remains localized to chromatin in the presence of SCHLAP1.

ABSTRACT: SCHLAP1 is a long noncoding RNA that is reported to function by depleting the SWI/SNF complex from the genome. We investigated the hypothesis that SCHLAP1 affects only specific compositions of SWI/SNF. Using several assays, we found that SWI/SNF is not depleted from the genome by SCHLAP1 and that SWI/SNF is associated with many coding and noncoding RNAs, suggesting that SCHLAP1 may function in a SWI/SNF-independent manner.

SUBMITTER: Raab JR 

PROVIDER: S-EPMC6339527 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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SWI/SNF remains localized to chromatin in the presence of SCHLAP1.

Raab Jesse R JR   Smith Keriayn N KN   Spear Camarie C CC   Manner Carl J CJ   Calabrese J Mauro JM   Magnuson Terry T  

Nature genetics 20181203 1

SCHLAP1 is a long noncoding RNA that is reported to function by depleting the SWI/SNF complex from the genome. We investigated the hypothesis that SCHLAP1 affects only specific compositions of SWI/SNF. Using several assays, we found that SWI/SNF is not depleted from the genome by SCHLAP1 and that SWI/SNF is associated with many coding and noncoding RNAs, suggesting that SCHLAP1 may function in a SWI/SNF-independent manner. ...[more]

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