Genomewide Association Study of Fracture Nonunion Using Electronic Health Records.

ABSTRACT: Nonunion is a clinically significant complication of fracture associated with worse outcomes, including increased pain, disability, and higher healthcare costs. The risk for nonunion is likely to be complex and multifactorial, and as such, the biology underlying such risk remains poorly understood. Genetic studies represent one approach to identify implicated biology for further investigation, but to date the lack of large cohorts for study has limited such efforts. We utilized the electronic health records of two large academic medical centers in Boston to identify individuals with fracture nonunion and control individuals with fracture but no evidence of nonunion. We conducted a genomewide association study among 1760 individuals of Northern European ancestry with upper or lower extremit

SUBMITTER: McCoy TH 

PROVIDER: S-EPMC6339539 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature