Modulation of human corneal stromal cell differentiation by hepatocyte growth factor and substratum compliance.

ABSTRACT: Corneal wound healing is a complex process that consists of cellular integration of multiple soluble biochemical cues and cellular responses to biophysical attributes associated with the matrix of the wound space. Upon corneal stromal wounding, the transformation of corneal fibroblasts to myofibroblasts is promoted by transforming growth factor-β (TGFβ). This process is critical for wound healing; however, excessive persistence of myofibroblasts in the wound space has been associated with corneal fibrosis resulting in severe vision loss. The objective of this study was to determine the effect of hepatocyte growth factor (HGF), which can modulate TGFβ signaling, on corneal myofibroblast transformation by analyzing the expression of α-smooth muscle actin (αSMA) as a marker of myofibroblast p

SUBMITTER: Miyagi H 

PROVIDER: S-EPMC6339683 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature