Microbial Agents as Putative Inducers of B Cell Lymphoma in Sjogren's Syndrome through an Impaired Epigenetic Control: The State-of-The-Art.

ABSTRACT:

Introduction

Understanding the mechanisms underlying the pathogenesis of Sjögren's syndrome (SS) is crucially important in order to be able to discriminate the steps that lead to B cell transformation and promptly identify the patients at risk of lymphomagenesis. The aim of this narrative review is to describe the evidence concerning the role that infections or dysbiosis plays in the epigenetic control of gene expression in SS patients and their possible involvement in B cell lymphomagenesis.

Materials and methods

We searched the PubMed and Google Scholar databases and selected a total of 92 articles published during the last 25 years that describe experimental and clinical studies of the potential associations of microbiota and epigenetic aberrations with the risk of B cell

SUBMITTER: Talotta R 

PROVIDER: S-EPMC6339763 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature