A klotho gene single nucleotide polymorphism is associated with the onset of stroke and plasma klotho concentration.

ABSTRACT: Klotho protects against development of multiple age-related disorders, including cardiovascular diseases. We assessed whether a human klotho single nucleotide polymorphism (SNP) rs650439 is associated with the onset of stroke in hypertensive patients and plasma klotho concentration in the general population. Five hundred and twenty-three patients with hypertension were analyzed for both the presence of rs650439 and onset of stroke. We found that hypertensive patients with the TT genotype of rs650439 (n=52) had a higher incidence of stroke than those with AT (n=257) and AA (n=214) genotypes. Multivariate analysis indicated that the TT genotype was the only risk factor associated with increased incidence of stroke. Plasma klotho concentrations were measured in a general

SUBMITTER: Yokoyama S 

PROVIDER: S-EPMC6339800 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature