Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transfer.

ABSTRACT: Highly enantioselective iridium catalyzed carbonyl (2-vinyl)allylation or "isoprenylation" is achieved via hydrogen auto-transfer or 2-propanol-mediated reductive coupling from primary alcohol or aldehyde reactants, respectively. Using this method, asymmetric total syntheses of the terpenoid natural products (+)-ipsenol and (+)-ipsdienol were achieved.

SUBMITTER: Xiang M 

PROVIDER: S-EPMC6339811 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature