Induction and Suppression of NF-κB Signalling by a DNA Virus of Drosophila.

ABSTRACT: Interactions between the insect immune system and RNA viruses have been extensively studied in Drosophila, in which RNA interference, NF-κB, and JAK-STAT pathways underlie antiviral immunity. In response to RNA interference, insect viruses have convergently evolved suppressors of this pathway that act by diverse mechanisms to permit viral replication. However, interactions between the insect immune system and DNA viruses have received less attention, primarily because few Drosophila-infecting DNA virus isolates are available. In this study, we used a recently isolated DNA virus of Drosophila melanogaster, Kallithea virus (KV; family Nudiviridae), to probe known antiviral immune responses and virus evasion tactics in the context of DNA virus infection. We found that fly mutants for RNA inte

SUBMITTER: Palmer WH 

PROVIDER: S-EPMC6340046 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature