Measurement of blood-brain barrier permeability using dynamic contrast-enhanced magnetic resonance imaging with reduced scan time.

ABSTRACT:

Purpose

To investigate the feasibility of measuring the subtle disruption of blood-brain barrier (BBB) using DCE-MRI with a scan duration shorter than 10 min.

Methods

The extended Patlak-model (EPM) was introduced to include the effect of plasma flow (F_p ) in the estimation of vascular permeability-surface area product (PS). Numerical simulation studies were carried out to investigate how the reduction in scan time affects the accuracy in estimating contrast kinetic parameters. DCE-MRI studies of the rat brain were conducted with Fisher rats to confirm the results from the simulation. Intracranial F98 glioblastoma models were used to assess areas with different levels of permeability. In the normal brain tissues, the Patlak model (PM) and EPM were compared, wherea

SUBMITTER: Bae J 

PROVIDER: S-EPMC6340058 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature