BioModelKit - An Integrative Framework for Multi-Scale Biomodel-Engineering.

ABSTRACT: While high-throughput technology, advanced techniques in biochemistry and molecular biology have become increasingly powerful, the coherent interpretation of experimental results in an integrative context is still a challenge. BioModelKit (BMK) approaches this challenge by offering an integrative and versatile framework for biomodel-engineering based on a modular modelling concept with the purpose: (i) to represent knowledge about molecular mechanisms by consistent executable sub-models (modules) given as Petri nets equipped with defined interfaces facilitating their reuse and recombination; (ii) to compose complex and integrative models from an ad hoc chosen set of modules including different omic and abstraction levels with the option to integrate spatial aspects; (iii) to promote the co

SUBMITTER: Blatke MA 

PROVIDER: S-EPMC6340123 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature