Word comprehension in temporal cortex and Wernicke area: A PPA perspective.

ABSTRACT:

Objective

To explore atrophy-deficit correlations of word comprehension and repetition in temporoparietal cortices encompassing the Wernicke area, based on patients with primary progressive aphasia (PPA).

Methods

Cortical thickness in regions within and outside the classical Wernicke area, measured by FreeSurfer, was correlated with repetition and single word comprehension scores in 73 right-handed patients at mild to moderate stages of PPA.

Results

Atrophy in the Wernicke area was correlated with repetition (r = 0.42, p = 0.001) but not single word comprehension (r = -0.072, p = 0.553). Correlations with word comprehension were confined to more anterior parts of the temporal lobe, especially its anterior third (r = 0.60, p <

SUBMITTER: Mesulam MM 

PROVIDER: S-EPMC6340389 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature