Preadmission use of benzodiazepines and stroke outcomes: the Biostroke prospective cohort study.

ABSTRACT:

Objectives

We tested the hypothesis that stroke outcomes in patients with preadmission use of benzodiazepine are worse.

Method

In a prospective cohort study, we recruited patients with acute ischaemic stroke. Mortality, functional outcomes and cognition were evaluated at 8 and 90 days after stroke.

Results

370 patients were included. 62 (18.5%) of the 336 remaining patients were treated with benzodiazepines when stroke occurred, and they did not receive any other psychotropic drug. The mortality rate was higher in benzodiazepines users than non-users at day 8 (2.2% vs 8.1%, p=0.034) and day 90 (8.1% vs 25.9%, p=0.0001). After controlling for baseline differences using propensity-score matching, only the difference in mortality rate at day 90 was of borderline of signi

SUBMITTER: Colin O 

PROVIDER: S-EPMC6340422 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature