Automated oxygen administration versus conventional oxygen therapy after major abdominal or thoracic surgery: study protocol for an international multicentre randomised controlled study.

ABSTRACT:

Introduction

Hypoxemia and hyperoxia may occur after surgery with potential related complications. The FreeO₂ PostOp trial is a prospective, multicentre, randomised controlled trial that evaluates the clinical impact of automated O₂ administration versus conventional O₂ therapy after major abdominal or thoracic surgeries. The study is powered to demonstrate benefits of automated oxygen titration and weaning in term of oxygenation, which is an important surrogate for complications after such interventions.

Methods and analysis

After extubation, patients are randomly assigned to the Standard (manual O₂ administration) or FreeO₂ group (automated closed-loop O₂ administration). Stratification is perf

SUBMITTER: L'her E 

PROVIDER: S-EPMC6340445 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature