PreImplantation Trial of Histopathology In renal Allografts (PITHIA): a stepped-wedge cluster randomised controlled trial protocol.

ABSTRACT:

Introduction

Most potential kidney transplant donors in the UK are aged over 60 years, yet increasing donor age is associated with poorer graft survival and function. Urgent preimplantation kidney biopsy can identify chronic injury, and may aid selection of better 'quality' kidneys from this group. However, the impact of biopsy on transplant numbers remains unproven. The PreImplantation Trial of Histopathology In renal Allografts (PITHIA) study will assess whether the introduction of a national, 24 hours, digital histopathology service increases the number, and improves outcomes, of kidneys transplanted in the UK from older deceased donors.

Methods and analysis

PITHIA is an open, multicentre, stepped-wedge cluster randomised study, involving all UK adult kidney transplant ce

SUBMITTER: Ayorinde JO 

PROVIDER: S-EPMC6340453 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature