Protocol for a feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients.

ABSTRACT:

Introduction

Oxygen is the most commonly administered drug to mechanically ventilated critically ill adults, yet little is known about the optimum oxygen saturation (SpO₂) target for these patients; the current standard of care is an SpO₂ of 96% or above. Small pilot studies have demonstrated that permissive hypoxaemia (aiming for a lower SpO₂ than normal by using a lower fractional inspired oxygen concentration (FIO₂)) can be achieved in the critically ill and appears to be safe. This approach has not been evaluated in a National Health Service setting. It is possible that permissive hypoxaemia may be beneficial to critically ill patients thus it requires robust evaluation.

Methods and analysis

Targeted OXygen therapY in Critical

SUBMITTER: Martin DS 

PROVIDER: S-EPMC6340470 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature