Genome-Wide Regulatory Adaptation Shapes Population-Level Genomic Landscapes in Heliconius.

ABSTRACT: Cis-regulatory evolution is an important engine of organismal diversification. Although recent studies have looked at genomic patterns of regulatory evolution between species, we still have a poor understanding of the magnitude and nature of regulatory variation within species. Here, we examine the evolution of regulatory element activity over wing development in three Heliconius erato butterfly populations to determine how regulatory variation is associated with population structure. We show that intraspecific divergence in chromatin accessibility and regulatory activity is abundant, and that regulatory variants are spatially clustered in the genome. Regions with strong population structure are highly enriched for regulatory variants, and enrichment patterns are associated with developmen

SUBMITTER: Lewis JJ 

PROVIDER: S-EPMC6340471 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature