Integrated analysis of lncRNA-associated ceRNA network reveals potential biomarkers for the prognosis of hepatitis B virus-related hepatocellular carcinoma.

ABSTRACT:

Background

There is evidence that abnormal expression of lncRNAs is associated with hepatitis B virus (HBV) infection-induced hepatocellular carcinoma (HCC). However, the mechanisms remain not fully elucidated. The study aimed to identify novel lncRNAs and explore their underlying mechanisms based on the ceRNA hypothesis.

Methods

The RNA and miRNA expression profiling in 20 tumor and matched adjacent tissues from HBV-HCC patients were retrieved from the Gene Expression Omnibus database under accession numbers GSE77509 and GSE76903, respectively. Differentially expressed lncRNAs (DELs), miRNAs (DEMs), and genes (DEGs) were identified using the EdgeR package. Protein-protein interaction (PPI) network was constructed for DEGs followed by module analysis. The ceRNA network was c

SUBMITTER: Li H 

PROVIDER: S-EPMC6340501 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature