The novel sugar transporter SLC50A1 as a potential serum-based diagnostic and prognostic biomarker for breast cancer.

ABSTRACT:

Background

The novel sugar transporter and membrane protein SLC50A1 has been identified as a potential candidate biomarker for breast cancer; however, its potential as a serum biomarker for breast cancer detection and prognosis is unclear. The aim of this study was to investigate the serum expression profile of SLC50A1 and to determine its diagnostic and prognostic significance in breast cancer.

Materials and methods

Bioinformatics analysis was conducted, and data for SLC50A1 expression in human breast cancer were collected. Semi-quantitative real-time PCR and ELISA were performed to compare SLC50A1 expression in several breast cancer cell lines, one paired tissue cohort (n=20) and two independent cohorts of human breast cancer patients (n=85) and healthy individuals

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6340503 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature