The Genetic Variation of CYP2D6 Gene in the Bosnian Population.

ABSTRACT:

Introduction

Genetic polymorphism is associated with individual responses to medication and susceptibility to diseases, and it represents the basis for individualized medical treatment and drug genomics studies. Genetic variation at CYP2D6 is high, both among populations and among individuals in the same population.

Aim

The aim of the study was to investigate the CYP2D6 gene duplication and the non-synonymous single-nucleotide polymorphisms (SNP) 100C>T in the CYP2D6 gene in members of the Bosnian population.

Material and methods

The blood samples were collected from 151 unrelated and healthy donors from Bosnian populations consisted of 94 females and 57 males. Duplex long-range PCR was used to determine whether individuals carrying CYP2

SUBMITTER: Nefic H 

PROVIDER: S-EPMC6340619 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature