CD133 expression in circulating hematopoietic progenitor cells.

ABSTRACT:

Background

Circulating hematopoietic progenitors (HPCs) are involved in inflammatory diseases such as atherosclerosis, the immune response to cancer, and disorders of the hematopoietic system. HPC characterization by flow cytometry typically utilizes CD34 in combination with other cell surface markers to identify cell populations that give rise to specific hematopoietic lineages. CD133, also known as prominin-1, is a cell surface protein found in HPCs that has a similar but not interchangeable expression pattern with CD34 for characterization of HPC populations. Our goal was to determine the distribution of CD133 expression within HPC sub-types amongst circulating CD34+ cells.

Methods

The quantity of different HPC populations within the CD34+ CD133+ and CD34+ CD133- fraction

SUBMITTER: Cimato TR 

PROVIDER: S-EPMC6340728 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature