Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair.

ABSTRACT: Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of bulky lesions from DNA and is characterized by an extraordinarily wide substrate specificity. Remarkably, the efficiency of lesion removal varies dramatically and certain lesions escape repair altogether and are therefore associated with high levels of mutagenicity. Central to the multistep mechanism of damage recognition in NER is the sensing of lesion-induced thermodynamic and structural alterations of DNA by the XPC-RAD23B protein and the verification of the damage by the transcription/repair factor TFIIH. Additional factors contribute to the process: UV-DDB, for the recognition of certain UV-induced lesions in particular in the context of chromatin, while the XPA protein is believed to have a role

SUBMITTER: Mu H 

PROVIDER: S-EPMC6340764 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature