A comparison of prostate cancer bone metastases on ¹⁸F-Sodium Fluoride and Prostate Specific Membrane Antigen (¹⁸F-PSMA) PET/CT: Discordant uptake in the same lesion.

ABSTRACT:

Purpose

Prostate-Specific Membrane Antigen (PSMA) PET/CT has been introduced as a sensitive method for characterizing metastatic prostate cancer. The purpose of this study is to compare the spatial concordance of ¹⁸F-NaF PET/CT and ¹⁸F-PSMA-targeted PET/CT within prostate cancer bone metastases.

Methods

Prostate cancer patients with known bone metastases underwent PSMA-targeted PET/CT (¹⁸F-DCFBC or ¹⁸F-DCFPyL) and ¹⁸F-NaF PET/CT. In pelvic and spinal lesions detected by both radiotracers, regions-of-interest (ROIs) derived by various thresholds of uptake intensity were compared for spatial colocalization. Overlap volume was correlated with uptake characteristics and disease status.

Results

The study included 149 l

SUBMITTER: Harmon SA 

PROVIDER: S-EPMC6340866 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature