A study of meiomitosis and novel pathways of genomic instability in cutaneous T-cell lymphomas (CTCL).

ABSTRACT: Genomic instability is a hallmark of cancer and an enabling factor for genetic alterations that drive cancer development and progression. The clashing of mitosis and aberrantly expressed meiosis machineries, which may contribute to genomic instability, has been coined cancer "meiomitosis". LINE-1 retrotransposition, a process active in germ cells, acts outside of the meiotic machinery to create DNA double strand breaks (DNA DSBs) and has played an important role in the evolution of the human genome. We have previously demonstrated that in CTCL several cancer testis/meiotic genes are expressed. Furthermore, this cancer exhibits extensive and ongoing chromosomal/microsatellite instability. In this study we analyzed immortalized patient-derived cells and primary CTCL patient samples us

SUBMITTER: Tsang M 

PROVIDER: S-EPMC6340880 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature