Spatial Principles of Chromatin Architecture Associated With Organ-Specific Gene Regulation.

ABSTRACT: Packaging of the genome in the nucleus is a non-random process that is thought to directly contribute to cell type-specific transcriptomes, although this hypothesis remains untested. Epigenome architecture, as assayed by chromatin conformation capture techniques, such as Hi-C, has recently been described in the mammalian cardiac myocyte and found to be remodeled in the setting of heart failure. In the present study, we sought to determine whether the structural features of the epigenome are conserved between different cell types by investigating Hi-C and RNA-seq data from heart and liver. Investigation of genes with enriched expression in heart or liver revealed nuanced interaction paradigms between organs: first, the log₂ ratios of heart:liver (or liver:heart) intrachromosomal

SUBMITTER: Chapski DJ 

PROVIDER: S-EPMC6341059 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature