Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression.

ABSTRACT: Alterations of the 5-HT_1A receptor and BDNF have consistently been associated with affective disorders. Two functional single nucleotide polymorphisms (SNPs), rs6295 of the serotonin 1A receptor gene (HTR1A) and rs6265 of brain-derived neurotrophic factor gene (BDNF), may impact transcriptional regulation and expression of the 5-HT_1A receptor. Here we investigated interaction effects of rs6295 and rs6265 on 5-HT_1A receptor binding. Forty-six healthy subjects were scanned with PET using the radioligand [carbonyl-¹¹C]WAY-100635. Genotyping was performed for rs6265 and rs6295. Subjects showing a genotype with at least three risk alleles (G of rs6295 or A of rs6265) were compared to control genotypes. Cortical surface binding potential (BP_ND

SUBMITTER: Kautzky A 

PROVIDER: S-EPMC6341100 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature