Neurodevelopment of breastfed HIV-exposed uninfected and HIV-unexposed children in South Africa.

ABSTRACT:

Objectives

To assess neurodevelopment of breastfed HIV-exposed uninfected (HEU) and breastfed HIV-unexposed children in the context of universal maternal antiretroviral therapy (ART).

Design

Prospective study with antenatal enrolment and follow-up of breastfeeding HEU and HIV-unexposed mother-infant pairs through 12-18 months postpartum.

Setting

Peri-urban community, Cape Town, South Africa.

Participants

HEU (n = 215) and HIV-unexposed (n = 306) children.

Main outcome measures

Cognitive, motor and language development at median 13 (interquartile range 12-14) months of age: continuous and dichotomous Bayley Scales of Infant and Toddler Development Third Edition (delay defined as composite score <85).

Results

Incidence of preterm delivery (<37 weeks

SUBMITTER: le Roux SM 

PROVIDER: S-EPMC6341164 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature