High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17⁺IL-10⁺ Memory CD4⁺ T Cell Response towards a Single IL-10-Producing Phenotype.

ABSTRACT: Glucocorticoids are known to increase production of the anti-inflammatory cytokine IL-10, and this action is associated with their clinical efficacy in asthmatics. However, glucocorticoids also enhance the synthesis of IL-17A by PBMCs, which, in excess, is associated with increased asthma severity and glucocorticoid-refractory disease. In this study, we show that the glucocorticoid dexamethasone significantly increased IL-10 production by human memory CD4⁺ T cells from healthy donors, as assessed by intracellular cytokine staining. In addition, dexamethasone increased production of IL-17A, IL-17F, and IL-22, with the most striking enhancement in cells coproducing Th17-associated cytokines together with IL-10. Of note, an increase in IFN-γ⁺IL-10⁺ cells was a

SUBMITTER: Mann EH 

PROVIDER: S-EPMC6341182 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature