Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.

ABSTRACT:

Objective

Pancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We also examined relationships among PV, AAB status, and endocrine and exocrine functions.

Research design and methods

We conducted a cross-sectional study that included five groups: AAB^- control subjects (no diabetes and no first- or second-degree relatives with type 1 diabetes) (N = 49), AAB^- FDRs (N = 61), AAB⁺ FDRs (N = 67 total: n = 31 with a single positive AAB [AAB⁺ single] and n

SUBMITTER: Campbell-Thompson ML 

PROVIDER: S-EPMC6341284 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature