Analysis of the rs2476601 polymorphism of PTPN22 in Mexican mestizo patients with leprosy.

ABSTRACT: Leprosy, a human chronic granulomatous disease caused by Mycobacterium leprae (M. leprae), remains endemic in certain countries despite the use of multidrug therapy. Recently, several host genes modulating the immune responses to M. leprae infection have been suggested to influence the acquisition and clinical course of leprosy. Lymphoid protein tyrosine phosphatase, encoded by the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, serves a negative regulatory role in T cell activation. The non-synonymous single-nucleotide polymorphism (SNP) rs2476601 (1858C>T) has been associated with autoimmune diseases. Here, the present study investigated if rs2476601 polymorphism was associated with leprosy in a Mexican mestizo population. Genotyping was performed in

SUBMITTER: Escamilla-Tilch M 

PROVIDER: S-EPMC6341406 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature