Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture.

ABSTRACT: Anterior cruciate ligament (ACL) rupture is one the most common musculoskeletal soft tissue injuries of the knee. Although the exact mechanisms of this injury remain uncertain, genetic variants have been considered to be an intrinsic risk factor associated with ACL rupture. Therefore, the aim of the present study was to determine whether the adiponectin +276G/T polymorphism is associated with susceptibility to ACL rupture in a Thai population. Genotyping for rs1501299 was conducted in 98 participants with ACL rupture and 95 healthy controls by polymerase chain reaction-restriction fragment length polymorphism analysis. The results demonstrated that the GG genotype and G allele were significantly associated with an increased risk of ACL rupture [odds ratio (OR)=1.91, P=0.026; OR=1.89, P=0.0

SUBMITTER: Udomsinprasert W 

PROVIDER: S-EPMC6341408 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature