Elevated Vancomycin Trough Levels in a Tertiary Health System: Frequency, Risk Factors, and Prognosis.

ABSTRACT:

Objective

To investigate the frequency of, risk factors for, and outcomes after elevated levels of vancomycin.

Patients and methods

We identified hospitalizations among 21,285 individuals in which intravenous vancomycin was given between August 29, 2007, and October 10, 2014. We investigated frequency and risk factors for elevated vancomycin levels (trough levels >30 mg/L) as well as associations with subsequent acute kidney injury (AKI), length of stay, and in-hospital mortality.

Results

Among the 21,285 patients, the mean age was 62.9 years, and 10,478 (49.2%) were female. Trough levels of vancomycin were checked in 7422 patients, and 755 elevated levels were detected. Compared with patients with trough levels checked but no elevated levels found, those with elevate

SUBMITTER: Zonozi R 

PROVIDER: S-EPMC6341482 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature