Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study.

ABSTRACT:

Objective

We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring.

Methods

The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3 to 4 months postpartum. Cumulative intakes of supplemental vitamin D and n-3 FAs were analyzed as continuous or binary variables. We applied time-to-ev

SUBMITTER: Silvis K 

PROVIDER: S-EPMC6341488 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature