Anti-Oxidant Drugs: Novelties and Clinical Implications in Cerebellar Ataxias.

ABSTRACT:

Background

Hereditary cerebellar ataxias are a group of disorders characterized by heterogeneous clinical manifestations, progressive clinical course, and diverse genetic causes. No disease modifying treatments are yet available for many of these disorders. Oxidative stress has been recurrently identified in different progressive cerebellar diseases, and it represents a widely investigated target for treatment.

Objective

To review the main aspects and new perspectives of antioxidant therapy in cerebellar ataxias ranging from bench to bedside.

Method

This article is a summary of the state-of-the-art on the use of antioxidant molecules in cerebellar ataxia treatments. It also briefly summarizes aspects of oxidative stress production and general characteristics of antiox

SUBMITTER: Barca E 

PROVIDER: S-EPMC6341493 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature