Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study.

ABSTRACT:

Background

High mammographic density is associated with breast cancer and with delayed detection. We have examined whether localized density, at the site of the subsequent cancer, is independently associated with being diagnosed with a large-sized or interval breast cancer.

Methods

Within a prospective cohort of 63,130 women, we examined 891 women who were diagnosed with incident breast cancer. For 386 women, retrospective localized density assessment was possible. The main outcomes were interval cancer vs. screen-detected cancer and large (> 2 cm) vs. small cancer. In negative screening mammograms, overall and localized density were classified reflecting the BI-RADS standard. Density concordance probabilities were estimated through multinomial regression. The associations b

SUBMITTER: Strand F 

PROVIDER: S-EPMC6341532 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature