Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming.

ABSTRACT:

Background

Although clinical data support an association between paternal alcohol use and deficits in child neurocognitive development, the relationship between paternal drinking and alcohol-induced growth phenotypes remains challenging to define. Using an established mouse model of chronic exposure, previous work by our group has linked preconception paternal alcohol use to sex-specific patterns of fetal growth restriction and placental dysfunction. The aim of the present study was to investigate the long-term impact of chronic preconception paternal alcohol use on offspring growth and metabolic programming.

Results

Preconception paternal alcohol exposure induced a prolonged period of fetal gestation and an increased incidence of intrauterine growth restriction, which affec

SUBMITTER: Chang RC 

PROVIDER: S-EPMC6341619 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature