Helicobacter pylori infection associated with an increased risk of colorectal adenomatous polyps in the Chinese population.

ABSTRACT:

Background

Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. pylori with colorectal adenomatous polyps (CAP) in the Chinese population.

Methods

One thousand three hundred seventy five workers of China Petroleum and Chemical Corporation Sinopec Zhenhai Refining & Chemical Branch were recruited. Carbon-13 urea breathes test, and colorectal biopsies were utilized to detect H. pylori and CAP. The correlation between the number and distribution of CAP with H. pylori infection (HPI) was determined. Logistic regression models were applied to calculate the effect of H. pylori on the risk of CAP and pathway studio was used to attribute the cellular proces

SUBMITTER: ChangxiChen 

PROVIDER: S-EPMC6341657 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature