Gene annotation errors are common in the mammalian mitochondrial genomes database.

ABSTRACT:

Background

Although animal mitochondrial DNA sequences are known to evolve rapidly, their gene arrangements often remain unchanged over long periods of evolutionary time. Therefore, comparisons of mitochondrial genomes may result in significant insights into the evolution both of organisms and of genomes. Mammalian mitochondrial genomes recently published in the GenBank database of NCBI show numerous rearrangements in various regions of the genome, from which it may be inferred that the mammalian mitochondrial genome is more dynamic than expected. However, it is alternatively possible that these are errors of annotation and, if so, are misleading our interpretations. In order to verify these possible errors of annotation, we performed a comparative genomic analysis of mammalian mit

SUBMITTER: Prada CF 

PROVIDER: S-EPMC6341679 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature