MiRNAs and target genes in the blood as biomarkers for the early diagnosis of Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is the second most common neurodegenerative disease, and it is a multifactorial disease with no definite diagnostic index. The aim of this study is to construct a molecular network to find molecules that play important roles in the progression of PD with the goal of using them diagnostically and for early intervention.

Results

We downloaded two gene expression profiles (GSE54536 and GSE100054) from the Expression Omnibus (GEO) database to analyze possible markers. The Genes were analyzed with GEO2R. There were 1790 and 967 differentially expressed genes (DEGs) in GSE54536 and GSE100054 respectively. A total of 125 genes co-exist in the DEGs of the two data sets. KEGG pathway analysis showed that 125 DEGs were enriched in Aldosterone synthe

SUBMITTER: Liu X 

PROVIDER: S-EPMC6341689 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature